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Miodarone Tablets (Amiodarone HCL 200mg)Monosor 40 Tablets (Isosorbide-5-mononitrate 40mg)

Monosor 20 Tablets (Isosorbide-5-mononitrate 20mg)
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Monosor 20 Tablets (Isosorbide-5-mononitrate 20mg)

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Antihypertensive
Composition:

Active ingredient: Isosorbide-5-Mononitrate
Monosor 20 Tablet:1 tablet of Monosor 20 contains IS-5-MN (Isosorbide-5-Mononitrate) 20mg
Monosor 40 Tablet:1 tablet of Monosor 40 contains IS-5-MN (Isosorbide-5-Mononitrate) 40mg

Indications:

Long-term treatment of coronary heart disease (CHD).
Prophylaxis of angina pectoris.
Treatment of pulmonary hypertension.
Treatment of chronic heart failure which is concomitantly being treated with glycosides and/or diuretics.
Follow-up treatment of myocardial infarction with persistent angina pectoris symptoms.

Contraindications:

Isosorbide-5-Mononitrate must not be used in:

Marked hypotension (BPmally declines after some days of continued treatment.
Occasionally particularly when first used slight states of dizziness or feelings of weakness may occur which normally decline during the treatment.

Occasionally especially at the beginning of treatment, postural hypotension, tachycardia or flushing, which normally decline on continuation of therapy.
Rarely collapse, occasionally accompanied by bradycardiac dysrhythmias or intensified symptoms of angina pectoris if there is a significant drop in blood pressure.

Occasionally especially when first used, nausea and/or vomiting.

Possible formation of methaemoglobin in patients with methaemoglobin-reductase deficiency as well as patients with diaphorase-deficiency and abnormal hemoglobin structure.

Interactions:

The concomitant ingestion of antihypertensives (e.g calcium channel blockers and other vasodilating drugs) tricyclic antidepressants or alcohol may potentiate the blood pressure lowering action of isosorbide-5-mononitrate.
Isosorbide-5-mononitrate can enhance the action of dihydroergotamine (DHE) by increasing the DHE plasma levels.

Dosage:

1 tablet of isosorbide-5-mononitrate 20 mg twice daily is the standard dosage which might be increased to 1 tablet three times daily if the individual requirement is higher.
In order to prevent or minimize nitrate headache it is recommended that the dose is reduced to half a tablet twice daily for the first 2 days then increased to 1 tablet twice daily for the next 2 days.

Afterwards the treatment can be maintained at this level or increased, if necessary to 1 tablet three times daily.

Method of administration:

The tablets should be swallowed unchewed with copious fluid after meals. If required 1 tablet can be taken shortly before going to sleep.

Special precaution for use:

In acute myocardial infraction isosorbide-5-mononitrate may only be given under strict medical supervision because reduction of the systolic blood pressure to below 90 mm Hg should be avoided. isosorbide-5-mononitrate should be used with caution in the pressure of orthostatic disorders of the circulatory regulation.I
sosorbide-5-mononitrate is not suitable for the treatment of acute angina pectoris attacks.
The intensity and frequency of ‚Äúnitrate headache‚ÄĚ which occurs particularly at the onset of treatment can generally be minimized by using lower initial doses which are gradually increased to therapeutic levels.

Stability

see expiry on the pack.

Pack
MONOSOR20 (Isosorbide-5-mononitrate 20mg tablets) 2x10’s Blister Pack
MONOSOR40 (Isosorbide-5-mononitrate 40mg tablets) 2x10’s Blister Pack