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Arja 320(Gemifloxacin Mesylate, 320mg)

Angipro Tablets (Enteric Coated Aspirin 75mg)
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Angipro Tablets (Enteric Coated Aspirin 75mg)

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(Acetyl Salicylic Acid)
Enteric Coated Aspirin Tablets

DESCRIPTION:

ANGIPRO is Enteric Coated Aspirin available in tablet form in 75mg

Structural Formula:

The enteric coated ANGIPRO is designed to resist disintegration in the stomach, but to dissolve in a better neutral to alkaline environment of the duodenum. Special enteric coating helps to protect the stomach from injury which may result from ingestion of plain, buffered or highly buffered aspirin, and the patients still gets the same serum salicylate levels and antiplatelet activity as with other form of aspirin.

INDICATIONS:

ANGIPRO (enteric coated Aspirin) is indicated for:
  • Angina Pectoris
  • Myocardial Infarction
  • Myocardial infarction prophylaxis
  • Transient Ischemic Attacks
Prophylactic use of ANGIPRO is also recommended to avoid the chances of thrombo embolic disorders

OTHER INDICATIONS:

ANGIPRO is also indicated in condition requiring chronic or long-term aspirin therapy for pain and inflammation, e.g. rheumatoid arthritis, Juvenile rheumatoid arthritis, Systemic lupus, erythematosus, Neurogenic bladder, Osteoarthritis, ankylosing spondylitis, psoriatic arthritis,

DOSAGE AND ADMINISTRATION:

Angina Pectoris / Myocardial Infarction:

The recommended dosage indicated for antiplatelet function, 75mg daily or as directed by the physician F Study in 333 USA Physicians with ‚Äúunstable angina‚ÄĚ indicated that low dose aspirin reduces the
risk for 1st myocardial infarction. ‚ÄúRef: Manson JE, et al. Aspirin in primary prevention of angina pectoris in randomized trial of USA physicians 1990‚ÄĚ FPatients with Silent Ischemia may benefit from low dose aspirin. Aspirin can be used as initial management to stop thrombosis progression and increase coronary blood flow. ‚ÄúRef: Redker PM et al, low dose aspirin therapy for chronic stable angina: a randomized, placebo control clinical trial‚ÄĚ Transient Ischemic Attacks For analgesic or anti-inflammatory indications. The dosage can be increased or modified according to the clinical situation of the individual patient under a physician's directions.

BIOAVAILABILITY:

The bioavailability of enteric coated aspirin has been demonstrated in a number of salicylate excretion studies. The studies show levels of salicylate (and metabolites) in urine excreted over 48 hours the enteric coated aspirin do not differ statistically from plain i.e, non enteric coated aspirin.
Plasma studies, in which enteric coated aspirin has been compared with plain aspirin in steady state studies over eight days, also demonstrated that enteric coated aspirin provides plasma salicylate levels not statistically different from plain aspirin.

Dissolution of the enteric coating occurs at a neutral to basic PH and is therefore dependent on gastric emptying into the duodenum. With continued dosing, appropriate plasma levels are maintained.

SAFETY:

The safety of enteric coated aspirin has been demonstraed in a number of endoscopic studies comparing it with plain aspirin as well as plain, buffered and arthritis strengths buffered preparations. All aspirin forms were given at a dose of 3900-4000mg per day for 14 days. The normal healthy volunteers participating in these studies were gastroscoped before and after the medication and 14 days drug free periods followed active drug. Compared to all the other preparations, there was significantly less gastric and duodenal damage during the course of the enteric coated aspirin.

WARNING:

Children and teenagers should not use this medicine for chickenpox or flu symptoms, before a doctor is consulted about Reye's syndrome, a rare but serious illness. If pain persists for more than 10 days, or if redness is present, or in arthritic or rheumatic conditions affecting children under 12 years consult a physician immediately. Discontinue use if dizziness, ringing in ears or impaired hearing occurs. if you experience persistent or unexplained stomach upset, consult your physician.
As with any medicine, in case of pregnancy and lactation the drug should be taken under medical advice.

ADVERSE REACTION:

Gastrointestinal Reactions:

Stomach pain (14.5%, 4.4%);heart burn(11.9%); nausea and or vomiting (7.6%, 2.1%); hospitalization for gastrointestinal disorder (4.9%, 3.5%)
In the AMIS and other trials, plain aspirin treated patients had increased rates of gross gastrointestinal bleeding. Symptoms and signs of gastrointestinal irritation were not significantly increased in subjects treated for unstable angina with buffered aspirin in solution.

PRESENTATION:

ANGIPRO (Aspirin 75mg per tablet) Blister pack of 30 enteric coated tablets.